What makes cells stop dividing and growing
Buildup of GATA4 protein pushes cell into static state of senescence, a change linked to aging
BUILDING UP Brain cells from older people (center) contained visibly greater amounts of the protein GATA4 (red) than brain cells from younger people (left). The chart compares the presence of the protein in young (blue) and old (red) cells. GATA4 plays a key role in switching on senescence, a cellular state linked with aging disorders.
C. Kang et al/SCIENCE 2015