More than 106,000 people died of drug overdoses in the United States in 2021. That’s more than the number of people who died due to firearm-related injuries (48,830), falls (44,686) or motor vehicle crashes (42,939). These are all considered preventable causes of death, and as such, they are a public health problem. Reducing the toll requires research to identify risk factors and then the development of interventions that make the environment safer and discourage unsafe behavior.