Not Like Clockwork: High-fat diet disrupts daily routines of mice

Most mice sleep, eat, and exercise on a predictable 24-hour cycle, thanks to their precise internal clocks. But mice fed a fatty diet have trouble sticking to their schedule, new research shows. Genetic activity, not just behavior, drives the changes.

Understanding this novel link between daily cycles, known as circadian rhythms, and the metabolic system could help reveal the mechanism behind some cases of obesity and diabetes in humans, scientists say.