I was surprised to find no mention of Linus Pauling’s theory of anesthesia in “Comfortably Numb” (SN: 7/3/04, p. 8: Comfortably Numb). In 1961, Pauling provided detailed arguments that interactions between anesthetic agents and water, rather than lipids, form hydrate microcrystals in the brain that entrap side chains of proteins and interfere with electrical oscillations.
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