Genetic tweaks built humans’ bigger brains

Experiments in mice show how to grow a wrinkled cortex

Big Brain

FOLD IT  A gene that only humans have can make the normally smooth outer layer of mouse brains develop folds similar to those in human brains (upper right center). The gene may have been important for the evolution of big human brains.

M. Florio and W. Huttner/Max Planck Institute of Molecular Cell Biology and Genetics

Human brains ballooned to about triple the size of their ancestors’ thanks to just a few genetic tweaks, new research suggests.