Genetic tweak turned plague bacterium deadly

Mutation in newly acquired gene transformed Yersinia pestis into a mass killer

Yersinia pestis bacteria

TINY KILLERS  Acquiring one gene and one mutation allowed these plague bacteria, Yersinia pestis (shown in yellow in a flea’s digestive system in this colored scanning electron micrograph), to cause deadly pandemics. 

NIAID

Two genetic changes turned the plague into a scourge.