Chemical tied to intergenerational obesity

Mice ingesting the compound tributyltin pass effects to grandchildren

Exposure in the womb to a chemical used in PVC and ship paint promotes obesity in mice. And the effect is long-lasting: The mice’s grandchildren were also fat despite no exposure to the chemical.

The work shows that the effects of an obesogen — a chemical that encourages fat accumulation — can be passed on to future generations not exposed to the chemical, researchers report online January 15 in Environmental Health Perspectives.