Bone regulators moonlight in the brain as fever inducers

Beauty may be only skin deep, but hot goes to the bone.

Proteins involved in breaking down bones are also part of the body’s thermostat, a new study shows. The proteins — a receptor called RANK and the protein that binds to it, called RANKL — turn up the heat to cause fever during infections and also help regulate daily temperature rhythms in female rodents, a study published in the Nov.