Contrary to the expectations of many mental-health clinicians, a large-scale study finds that severe depression in patients with bipolar disorder responds no better to a combination of antidepressant medications and mood-stabilizing drugs than it does to mood stabilizers alone.
In another challenge to clinical lore, the federally funded investigation indicates that antidepressant use doesn’t hasten the emergence of manic symptoms, such as grandiose thinking and euphoric feelings, in patients with bipolar disorder.
Log in
Subscribers, enter your e-mail address for full access to the Science News archives and digital editions.