Antibodies to fight Alzheimer’s may have unexpected consequences

Treatment that targets amyloid-beta plaque buildup makes mouse nerve cells hyperactive

In an unexpected twist, two antibodies designed to fight Alzheimer’s disease instead made nerve cells in mice misbehave more.

The results, published online November 9 in Nature Neuroscience, highlight how little is known about how these drugs actually work, says study coauthor Marc Aurel Busche of Technical University Munich.