By impeding estrogen’s cancer-promoting properties, the drug tamoxifen has enabled thousands of breast cancer patients to fend off recurrences. But taking tamoxifen increases the frequency of hot flashes, and many women use antidepressants to limit this side effect.
Researchers now report that popular antidepressants called selective serotonin reuptake inhibitors (SSRIs) might diminish the effectiveness of tamoxifen by limiting its conversion into medicinally important agents.
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